CEREBRAL VENOUS THROMBOSIS AND SARS-COV-2

Abstract

The SARS-CoV-2 virus is responsible for the disease known as covid-19, which appeared in China and spread rapidly around the world, causing a pandemic. In addition to respiratory symptoms, the disease is characterized by high fever and recently, neurological symptoms have been described. Thus, it is intended to provide information on the relationship between Covid-19 infection and central venous thrombosis. The present study was conducted by searching for studies published in the Scielo and PubMed databases, using the descriptors related to coronavirus, neurology and cerebral venous thrombosis. After investigation, 32 articles were listed, of which 25 were selected, according to their relevance and publication in high impact journals. SARS-CoV-2 binds to the ECA-2 receptor to infect human cells, so cells that express ECA-2 can act as targets. As it is a receptor located in neurons, glial cells and vascular endothelium, it is believed that the neurological symptoms are due to the direct invasion of the virus in the Central Nervous System (CNS), which can happen by hematogenous dissemination after pulmonary infection, through the barrier. hematoencephalic weakened by systemic or trans neuronal inflammation, preferably reaching the brain stem. Severe inflammation, including an “inflammatory storm” caused by cytokines, can lead to thrombosis, making patients prone to cerebrovascular, thrombotic and hemorrhagic events. Neurological complications in SARS-CoV-2 infection and cerebral venous thrombosis can be found among the different phenomena associated with the infection, requiring a high level of suspicion for the adequate treatment of these patients from the early stages.